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The vitamin D 3 and calcium supplements did not reduce breast cancer incidence, and 25(OH)D levels at the start of the study were not associated with breast cancer risk [ 99]. Individuals with a body mass index (BMI) of 30 or more have lower serum 25(OH)D levels than individuals without obesity.
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Vitamin D helps regulate the renin-angiotensin-aldosterone system (and thereby blood pressure), vascular cell growth, and inflammatory and fibrotic pathways [ 118].
The FDA developed DVs to help consumers compare the nutrient contents of foods and dietary supplements within the context of a total diet.
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Observational studies suggest that adequate vitamin D levels might reduce the risk of contracting MS and, once MS is present, decrease the risk of relapse and slow the disease's progression [ 138]. A case-control analysis of 1,695 cases of prostate cancer and 1,682 controls found no associations between 25(OH)D levels and prostate cancer risk [ 110].Some people will not make enough vitamin D from sunlight because they have very little or no sunshine exposure.
